I can't run worth crap in the game. Maybe its the AI being smart though - I am playing with the Bills so my main weapon is Lynch and since I insist on starting "Sexy Boy" JP Losman, I have to run the ball almost every down.
I have switched back and forth in my dynasty between Losman and Edwards. With Losman, I make a bunch of short passes, get overconfident, then bomb one downfield for Evans and it gets intercepted. With Edwards, I play well for 3 quarters, then I get chased from the pocket and either throw the ball to the defenders or get sacked and fumble. At least I am 2-0 with Losman. I lost my game against Jacksonville in the last quarter after throwing my second pick with Edwards. Worst part was that it was tied 10-10 with less then a minute left and I was on the Jacksonville 23 when it happened (they had their timeouts left, thats why I wasnt burning clock).